产品简介
1.Human sCD141 ELISA KIT Intended useThe Diaclone sCD141 ELISA kit is a solid phase sandwich ELISA for the in-vitro qual
公司简介
北京科瑞美科技有限公司是一家专门从事临床实验室产品销售及售后服务的高新技术企业。经过几年的不懈努力,以及广大用户的肯定与支持,已成为国内的生物试剂和仪器供应商。
科瑞美公司以引进“新产品、新技术”为己任,目前已拥有四十多家国外品牌,产品涉及重组蛋白、抗体、细胞因子、骨代谢、传染病、肿瘤、激素、心肌标志物、糖尿病、自身免疫、蛋白质芯片、优生优育、不孕不育等众多领域。相当多的产品和相关技术在国内的推广与国外几乎是同步的,为广大的科研工作者提供了有力的支持。
多年来我们不断推陈出新,积极倡导“锐意进取、精益求精、信守承诺、探索求新”的企业精神,以“保证质量,提高客户满意度”为经营宗旨,以质量求生存,以品种求发展,以科学技术为先导,致力于中国检验领域的缜密科学。面对未来,我们将一如既往的提供高质量的产品、优惠的价格及优质的服务。并秉持“专业、真诚”的服务宗旨,期待着与您在为广阔的天地里,成就共同发展,共创双赢的目标!期待着与您的合作!
我们坚信,只有不断创新,不断进步,我们才有强大的生命力!
展开
产品说明
1.Human sCD141 ELISA KIT Intended use
The Diaclone sCD141 ELISA kit is a solid phase sandwich ELISA for the in-vitro qualitative and quantitative determination of sCD141 in supernatants, buffered solutions or serum and plasma samples. This assay will recognise both natural and recombinant human sCD141.This kit has been configured for research only. Not suitable for use in therapeutic procedures.
2. Human sCD141 ELISA KIT Introduction
2.1. Summary
CD141 , also known as Thrombomodulin or BDC-A is an transmembrane protein expressed predominantly on the surface of vascular endothelial cells, but also on other cell types such as macrophages, monocytes, subpopulation of myeloid dendritic cells and keratinocytes. Thrombomodulin is a type 1 membrane glycoprotein of 74kDa consisting on a single chain with 6 Epidermal Growth Factor (EGF)-like domains critical for Thrombin and proteine C binding, and four other domains (an N-terminal C-type lectin domain, a highly glycosylated serine/threonine-rich domain, a transmembrane segment, and a short C-terminal cytoplasmic tail. It acts as an important component in the anti-coagulation and fibrinolysis system : cofactor for active thrombin, the thrombomodulin-thrombin complex activates protein C to degrade coagulation factors, inhibiting coagulation and fibrinolysis. (1-5) When vascular endothelial cells injury occurs, proteolytic cleavage release multiple fragments of thrombomodulin in circulation, so it represents a good marker for endothelial cell damage in pathologies such as cardiovascular disease, acute coronary syndrome, pulmonary thromboembolism or severe hemorrhage.(6-8). Thrombomodulin has been described as an anticoagulant effect protein, and its therapeutical potential for preventing deep vein thrombosis and its use in the treatment of disseminated intravascular coagulation is under demonstrated in preliminary data.(9-11) More recently, other biological effects beyond anticoagulation have been demonstrated such as an antiinflammatory
, cell adhesion and proliferation regulation It is also demonstrated that thrombomodulin may
be able to suppress the metastatic capacity of tumor cells, and hence have a protective role in many types of malignancies. (12-14)
公司网址:www.craymeibio.com
本页产品地址:http://www.yi7.com/sell/show-4017118.html