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96T Human sCD25 ELISA Kit

北京科瑞美科技有限公司

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价格：电议

所在地：北京

型号：96T

更新时间：2024-04-22

浏览次数：1130

公司地址：北京市海淀区厢黄旗2号楼1层4-179室

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产品简介

1. Human sCD25 (IL-2R) ELISA KIT Intended useThe Diaclone sCD25 ELISA kit is a solid phase sandwich ELISA for the in-vit

公司简介

北京科瑞美科技有限公司是一家专门从事临床实验室产品销售及售后服务的高新技术企业。经过几年的不懈努力，以及广大用户的肯定与支持，已成为国内的生物试剂和仪器供应商。

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产品说明

1. Human sCD25 (IL-2R) ELISA KIT Intended use
The Diaclone sCD25 ELISA kit is a solid phase sandwich ELISA for the in-vitro qualitative and quantitative determination of sCD25 in supernatants, buffered solutions or serum and plasma samples. This assay will recognise both natural and recombinant human sCD25.This kit has been configured research only. Not suitable for use in therapeutic procedures.

2.Human sCD25 (IL-2R) ELISA KIT Introduction
2.1. Summary
IL-2, one of the most important factors in the human immune system, is a potent T-cell growth factor whose major function is the activation of many cells of the immune system including T-cells, B-cells, macrophages and NK cells. These potent actions are mediated by IL-2 binding and signalling through its associated cell surface receptor IL-2R. This receptor is not expressed on normal or unstimulated lymphocytes but is quickly transcribed and expressed on T-cells following activation.

This IL-2R is a heterotrimeric protein consisting of three distinct glycopeptide subunits termed IL-2Ra (CD25) specific to IL-2R, IL-2Rb and IL-2Rg. The a and b chains are involved in binding IL-2 while the signal transduction following IL-2 binding is mediated by the g-chain along with the b chain. The IL-2Ra chain or CD25 is a type 1 transmembrane glycoprotein of 251 amino acids and 55kDa. CD25 can also be found as a soluble form in serum and tissue following enzymatic cleavage from expressing cells and can be identified as a 45KDa protein once shed from the membrane. As the expression and subsequent release of CD25 takes place following cell stimulation the presence of soluble CD25 (sCD25) in circulation is an excellent marker of T-cell activation.

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