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96T Human FGF-19 ELISA Kit

北京科瑞美科技有限公司

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价格：电议

所在地：北京

型号：96T

更新时间：2023-07-06

浏览次数：1264

公司地址：北京市海淀区厢黄旗2号楼1层4-179室

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产品简介

产品名称：Human FGF-19 ELISA Kit货号：RD0R1. INTENDED USEThe RD0R Human FGF-19 ELISA is a sandwich enzym

公司简介

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产品说明

产品名称：Human FGF-19 ELISA Kit
货号：RD191107200R
1. INTENDED USE
The RD191107200R Human FGF-19 ELISA is a sandwich enzyme immunoassay
for the quantitative measurement of human fibroblast growth factor-19 (FGF-19).

2.Features
· It is intended for research use only
· The total assay time is less than 3.5 hours
· The kit measures FGF-19 in serum and plasma (EDTA, citrate, heparin)
· Assay format is 96 wells
· Standard and Quality Controls are recombinant protein based
· Components of the kit are provided ready to use, concentrated or lyophilized

3. INTRODUCTION
Fibroblast growth factors (FGFs) are a large family of small (17-26 kDa) polypeptide growth
factors found in organisms ranging from nematodes to humans. The FGF family has at least
22 members in vertebrates and share 13-71% amino acid identity. The initial characterization
of these proteins focused on their ability to stimulate fibroblast proliferation. During embryonic
development, FGFs have diverse roles in regulating cell proliferation, migration and
differentiation. In the adult organism, FGFs are homeostatic factors and function in tissue
repair and response to injury.

FGF signaling is mediated through one of four FGF receptors (FGFR1-FGFR4), a complex
family of transmembrane receptor tyrosine kinases. FGFR5 has also been described, but
lacks the kinase domain and signaling capability. FGFs have a high affinity for heparin sulfate
proteoglycans and require heparin sulfate to activate FGF receptors. Although multiple FGFs
interact with each of the four FGFRs, a novel fibroblast growth factor FGF-19 exhibits exclusive binding to only one of FGF receptors (FGFR4).

The normal function of FGF-19 has not been resolved, although its role in inner ear
development has been suggested. It has been also found that hepatocyte expression
of FGF-19 is induced by the transcription factor, farnesoid X receptor (FXR). FXR is a key
regulator of cholesterol metabolism through suppression of the catabolic enzyme cyp7a,
the first and rate-limiting step in the biosynthesis of bile acids (BA). A recent study found that,
in humans, circulating FGF-19 has a diurnal rhythm controlled by the transintestinal BA flux,
and that FGF-19 modulates hepatic BA synthesis. Through its systemic effects, circulating
FGF-19 may also mediate other known BA-dependent effects on lipid and carbohydrate
metabolism.

In transgenic mice expressing human FGF-19, researchers found a significant increased
metabolic rate as well as decreased body weight and adiposity. Additionally, resistance to both diet-induced obesity and insulin desensitization were found. Similar responses have been
observed when recombinant FGF-19 was injected into the mice. However, it has been shown
too, that FGF-19 transgenic mice develop hepatic adrenocarcinomas with age, and
recombinant FGF-19 treated mice exhibit proliferation of hepatocytes.

Cross-Reactivity

human	Yes
bovine	Non-detectable
cat	Not tested
chicken	Not tested
dog	Not tested
goat	Non-detectable
hamster	Non-detectable
horse	Yes (recommended dilution 1:3)
monkey	Yes (recommended dilution 1:3)
mouse	Non-detectable
pig	Not tested
rabbit	Non-detectable
rat	Non-detectable
sheep	Non-detectable

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