HTI PAHFVII-S 1 mg-Sheep anti-Human Factor VII

Storage: Store between 10 and 20oC. Product will become viscous but

Storage: Store between –10 and –20oC.  Product will become viscous  but will not freeze.  Avoid storage in frost-free freezers.  Keep vial tightly capped.  Allow product to warm to room temperature and gently mix before use.
Description of Factor VII (F.VII)
Factor VII (F.VII, also known as Stable Factor and Proconvertin) is a vitamin K-dependent glycoprotein produced in the liver.  Plasma concentration of F.VII is normally ~0.5 µg/ml (10 nM) in plasma. A deficiency of F.VII is associated with bleeding in a clinical pattern similar to haemophilia, but is inherited as an autosomal recessive trait.  The deficiency can be characterized by a quantitative (low activity and low antigen)or a qualitative (low activity and normal antigen) defect in F.VII function.  In its zymogen form F.VII is a single chain molecule of ~50 kDa. It contains two EGF-like domains and an amino-terminal domain containing 10  γ-carboxyglutamic acid (Gla) residues. These Gla residues allow F.VII to bind divalent metal ions and participate in calcium-dependent binding interactions.  F.VII and  activated F.VII (F.VIIa) bind to tissue factor exposed at the site of vascular injury.  F.IXa, F.Xa or F.VIIa rapidly activate tissue factor-bound F.VII to F.VIIa in the presence of calcium and phospholipid. Thrombin and F.XIIa are able to activate F.VII in the fluid phase in the absence of cofactors.  The activation of the single chain zymogen F.VII occurs by proteolysis after residue Arg152, resulting in a two-chain active serine protease consisting of a 30 kDa heavy chain and an 18 kDa light chain.  In complex with tissue factor, phospholipid
and calcium, F.VIIa is able to activate F.X and F.IX.  Free F.VIIa in plasma is remarkably stable, but the activity of F.VIIa/TF complex is regulated by Tissue Factor Pathway Inhibitor (TFPI) in the presence of F.Xa, and also by Antithrombin (ATIII) in the presence of heparin1-3.

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