中文名称 畸形表皮自调节因子1抗体
规 格 0.1ml 0.2ml
研究领域 细胞生物 细胞周期蛋白 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, Chicken, Dog, Cow, Horse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 畸形表皮自调节因子1抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/co
分 子 量 59kDa
细胞定位 细胞核 细胞浆 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH co
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one mo
畸形表皮自调节因子1抗体产品介绍 background:
Suppressin, also known as DEAF1 is a trans
Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.
Function:
Trans
Subunit:
Homodimer (Probable). Isoform 1 and isoform 4 may form a heterodimer. Binds to LMO4 (via its C-terminus), LMO2 and CLIM2. May interact with the corepressor NCOR.
Subcellular Location:
Isoform 1: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear ex
Isoform 2: Secreted. Note=Secreted in some cell types.
Isoform 3: Secreted. Note=Secreted in some cell types.
Isoform 4: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.
Tissue Specificity:
Expressed in various tissues and cells such as in peripheral mo