产品简介
产品名称:Mouse/Rat FGF-21 ELISA Kit 产地:捷克规格:96T货号:RD0R1. INTENDED USEThe RD0R Mouse and Rat
公司简介
北京科瑞美科技有限公司是一家专门从事临床实验室产品销售及售后服务的高新技术企业。经过几年的不懈努力,以及广大用户的肯定与支持,已成为国内的生物试剂和仪器供应商。
科瑞美公司以引进“新产品、新技术”为己任,目前已拥有四十多家国外品牌,产品涉及重组蛋白、抗体、细胞因子、骨代谢、传染病、肿瘤、激素、心肌标志物、糖尿病、自身免疫、蛋白质芯片、优生优育、不孕不育等众多领域。相当多的产品和相关技术在国内的推广与国外几乎是同步的,为广大的科研工作者提供了有力的支持。
多年来我们不断推陈出新,积极倡导“锐意进取、精益求精、信守承诺、探索求新”的企业精神,以“保证质量,提高客户满意度”为经营宗旨,以质量求生存,以品种求发展,以科学技术为先导,致力于中国检验领域的缜密科学。面对未来,我们将一如既往的提供高质量的产品、优惠的价格及优质的服务。并秉持“专业、真诚”的服务宗旨,期待着与您在为广阔的天地里,成就共同发展,共创双赢的目标!期待着与您的合作!
我们坚信,只有不断创新,不断进步,我们才有强大的生命力!
展开
产品说明
产品名称:Mouse/Rat FGF-21 ELISA Kit
产地:捷克
规格:96T
货号:RD291108200R
1. INTENDED USE
The RD291108200R Mouse and Rat FGF-21 ELISA is a sandwich enzyme immunoassay for
the quantitative measurement of mouse and/or rat FGF-21 (fibroblast growth factor-21).
2.Features
· It is intended for research use only
· The total assay time is less than 3.5 hours
· The kit measures FGF-21 in serum
· Assay format is 96 wells
· Quality Controls are mouse and rat serum based. No human sera are used
· Standard is mouse recombinant protein based
· Components of the kit are provided ready to use, concentrated or lyophilized
3. INTRODUCTION
The fibroblast growth factor family (FGFs) are a family of more than 20 small (17-26 kDa)
secreted peptides. The initial characterisation of these proteins focused on their ability to
stimulate fibroblast proliferation through FGF receptors ( FGFRs). Members of FGFs family play important roles in defining and regulating the development and function of endocrine tissues as well as modulating various metabolic processes.
A recently described member of FGFs family, FGF-21, also called Fibroblast growth factor 21
precursor and UNQ3115/PRO10196, has been characterised as a potent metabolic regulator.
FGF-21 is preferentially expressed in liver and regulates glucose uptake in fat cells. Moreover,
therapeutic administration of FGF-21 decreased plasma glucose levels and triglycerides to
near normal levels in multiple mouse models of type 2 diabetes. Short-term treatment of
normal or db/db mice with FGF-21 lowered plasma levels of insulin and improved glucose
clearance compared with vehicle after oral glucose tolerance testing. Constant infusion of
FGF-21 for 8 weeks in db/db mice nearly normalized fed blood glucose levels and increased
plasma insulin levels. When administrated daily for 6 weeks to diabetic rhesus monkeys,
FGF-21 caused dramatic decline in fasting plasma glucose, fructosamine, triglicerides, insulin,and glucagon. FGF-21 administration also led to significant improvements in lipoprotein
profiles, including lowering of low-density lipoprotein cholesterol and raising of high-density
lipoprotein cholesterol as well as beneficial changes in the circulating levels of several
cardiovascular risk factors.
FGF-21, when overexpressed, protected animals from diet-induced obesity. These results
define a functional role for FGF-21 in vivo and provide evidence that FGF-21 can lower glucose and triglyceride levels in diabetic animals.
In contrast to several members of the FGF family which may induce therapeutically undesirable in vivo proliferation of various cell types, a recent study demonstrated that FGF-21 did not induce mitogenicity, hypoglycemia or weight gain at any dose tested in diabetic or healthy animals or when overexpressed in transgenic mice. Thus, FGF-21 appears to have
considerable potential for the treatment of diabetes mellitus.
网址:http://www.craymeibio.com/
本页产品地址:http://www.yi7.com/sell/show-4218911.html