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价格:电议
所在地:北京
型号:C-6000
更新时间:2020-08-26
浏览次数:905
公司地址:北京市海淀区西三旗悦秀路99号通厦公元99一号楼305室
刘桂山(先生)
M.W. 1202.61 |
C62H111N11O12 |
[59865-13-3] |
M.I. 12: 2821 |
M.I. 14: 2752 |
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 200 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A
Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. Donjerkovic, D., et al. "Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium." Cell. Growth Differ. 10: 695-704 (1999). Mordvinov, V.A., et al. "A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression." J. Immunol. Methods 228: 163-168 (1999). Zaidan, E., et al. "Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats." J. Neurochem. 73: 2214-2217 (1999). Gottschalk, A.R., et al. "Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2." Proc. Natl. Acad. Sci. USA 91: 7350-7354 (1994).
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