呋塞米

呋塞米英文名称：furosemide英文别名：Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid；4-Chloro-N-Furfuryl-5-Sulfamoylanthr

 武汉大华伟业医药化工有限公司以中国为基地，以的化学技术、医学技术为专业主体，是集科研、开发、生产经营为一体高科技企业、公司座落在武汉市江岸经济开发区岱家山45号，占地面积200多亩，有1个中试车间，3个多用生产车间（2个化学合成车间，2个生物合成车间，公司职工160名，其中以知名的专家为首，与技工紧密结合的40名专业技术人员，包括10名 高级工程师和15名工程师，是一支具有专业背景、朝气蓬勃、有高度创造天赋的团队。

公司主要从事原料药（API）及其中间体的研发和生产。根据国内外市场需求，以研发为先导，着重于新产品和创新工艺的工业化，现已开发投产20多种产品，已发展成为一个具备一定规模和实力的科研生产实体。公司主要产品有硝酸咪康唑，左旋肉碱，甲硝唑，维生素C，丙酸氯倍他索，地塞米松等，产品面向国际市场，以销往欧、美、亚太、香港、台湾等20多个国家和地区，产品为FDA检查的DMF工作也在进行中，公司率先通过ISO9002质量体系认证把产品质量作为企业的核心和生命。

武汉大华伟业医药化工有限公司秉承以人为本 、事求卓越、和谐共生的核心价值                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       &

呋塞米
英文名称：furosemide
英文别名：Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid；4-Chloro-N-Furfuryl-5-Sulfamoylanthranilic Acid；Lasix；Frusemide’
CAS号：54-31-9
分子式：C12H11ClN2O5S
分子量：330.74400
质量：330.00800
外观与性状：白色粉末
密度：1.606
熔点：220 °C (dec.)(lit.)
呋塞米又称呋喃苯胺酸、速尿、速尿灵、利尿灵、利尿磺胺、腹安酸，是一种作用于髓袢升支髓质部的氨磺酰类利尿药，有强而短暂的利尿作用，能增加水、钠、氯、钾、钙、镁、磷酸盐等的排泄。主要抑制髓袢升支粗段的髓质部及皮质部对Na+及Cl-的重吸收，促进钠、氯、钾的排出和影响肾髓质高渗透压的形成，干扰尿液的浓缩和稀释过程，使尿量增加。本品能抑制前列腺素分解酶的活性，使前列腺素E2的含量升高，有扩张血管的作用，对近曲小管、肾小球滤过也有作用，能增加肾血流量，调整肾内血流分布，使髓质血流量减少，表层皮质的血流量增加，促进利尿，作用迅速强大，多用于其他利尿药无效的病例。临床上用于治疗心性水肿、肾性水肿、肝硬化腹水、机能障碍或血管障碍所引起的周围性水肿，并可促进上部尿道结石的排泄。静脉给药可治疗脑水肿，在脑水肿药物中毒时也可加速毒物的排泄。需要注意的是呋塞米利尿时，由于尿中Cl-、Na+、K+、H+排出的增加，HCO3-的排出并不增加，长期反复用药或大量用药可引发低盐综合征、低氯低钾性碱中毒。
近年研究人员发现呋塞米雾化吸入有明显平喘作用，与色甘酸钠相同，抑制过敏介质释放，抑制神经递质乙酰胆碱、P物质的释放，可能与其能抑制氯离子进入呼吸道细胞膜有关。临床试用于运动性哮喘、抗原引起的速发型和迟发型哮喘

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