衰变加速因子蛋白16抗体用途说明

英文名称    DAF16    
中文名称    衰变加速因子蛋白16抗体    
别    名    DAF-16; DAF 16; Decay Accelerating Factor16.    
研究领域    细胞生物  发育生物学  信号转导  新陈代谢      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, elegans    
产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 衰变加速因子蛋白16抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    42-48kDa    
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DAF16/Decay Accelerating Factor16    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

衰变加速因子蛋白16抗体简介 background:
DAF-2, DAF-16 and AGE-1 (also known as DAF-23) regulate lifespan via an insulin-signaling pathway. In specific, decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. DAF-16 encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans HNF-3 activity is antagonized by insulin, causing the down regulation of developmental genes, raising the possibility that aspects of the DAF-16 regulatory system have been conserved. The gene AGE-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits and is required fornon-dauer development and normal senescence. CLK-1, a homolog of the yeast COQ7/CAT5 protein, is thought to exert its effects on longevity via the synthesis of ubiquinone, an essential component of electron transport.

important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.