冷休克蛋白DBPA抗体应用说明

中文名称    冷休克蛋白DBPA抗体    
英文名称    DBPA
别    名    Cold shock domain containing protein A; Cold shock domain protein A; Cold shock domain-containing protein A; csdA; CSDA1; DBPA; DBPA_HUMAN; DNA binding protein A; DNA-binding protein A; Single strand DNA binding protein NF GMB; Single-strand DNA-binding protein NF-GMB; ZO 1 associated nucleic acid binding protein; ZO1 associated nucleic acid binding protein; ZONAB.     
研究领域    细胞生物  信号转导  细胞周期蛋白  转录调节因子  表观遗传学      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     
产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 冷休克蛋白DBPA抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    40kDa    
细胞定位    细胞核 细胞浆     
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DBPA/CSDA1    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  
 
冷休克蛋白DBPA抗体产品介绍    background:
CSDA is a 372 amino acid nuclear and cytoplasmic protein that is highly expressed in skeletal muscle and heart. Containing one CSD (cold-shock) domain, CSDA is thought to bind to GM-CSF promoter, full length mRNA and to short RNA sequences containing a specific consensus site. CSDA is suggested to have a role in translation repression and is found in a mRNP complex with MSY2. MSY2 belongs to the Y-box family of multifunctional proteins that regulate both transcription and translation. CSDA participates in promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA). CSDA is regarded to be an important component of the mechanisms that sense epithelial density and in regulating the switch between proliferation and differentiation through complex transcriptional networks.

Function:
Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression.

Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Highly expressed in skeletal muscle and heart.

Similarity:
Contains 1 CSD (cold-shock) domain.