无精症缺失基因1抗体 产品介绍

英文名称  Anti-DAZ1
中文名称  无精症缺失基因1抗体
别    名  DAZ 1; DAZ; Deleted in azoospermia 1; Deleted in azoospermia; Deleted in azoospermia protein 1; SPGY; DAZ1_HUMAN.          
浓    度  1mg/1ml
规 格  0.2ml/200μg          
抗体来源  Rabbit  
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep   
产品类型  一抗    
研究领域  细胞生物 发育生物学 信号转导 干细胞 表观遗传学  
蛋白分子量  predicted molecular weight: 83kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from Human DAZ1
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

无精症缺失基因1抗体产品介绍 DAZ1 (deleted in azoospermia 1) is an RNA-binding protein that is essential in spermatogenesis. It may regulate translation of mRNAs by binding to the 3'-UTR.

Function : RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.
Subunit : Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.
Subcellular Location : Cytoplasmic and Nuclear.Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Tissue Specificity : Testis-specific. expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level).
DISEASE : Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.

Similarity : Belongs to the RRM DAZ family.
Contains 9 DAZ-like domains.
Contains 3 RRM (RNA recognition motif) domains.
Database links : UniProtKB/Swiss-Prot: Q9NQZ3.2