含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体说明书

 中文名称  含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体
别    名  Ankyrin repeat and SOCS box 2 containing protein; Ankyrin repeat and SOCS box containing 2; Ankyrin repeat and SOCS box containing protein 2; Ankyrin repeat containing protein ASB2.ASB2_HUMAN
浓    度  1mg/1ml
规 格  0.2ml/200μg          
抗体来源  Rabbit  
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Pig, Cow, Horse   
产品类型  一抗    
研究领域  细胞生物 染色质和核信号 信号转导 细胞周期蛋白 转录调节因子 表观遗传学  
蛋白分子量  predicted molecular weight: 65kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Drebrin.
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体产品介绍 The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

Function : Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Subunit : Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 and TCEB2) and ASB2

Similarity : Contains 12 ANK repeats
Contains 1 SOCS box domain.