胞质分裂专一蛋白7抗体实验说明

产品名称：胞质分裂专一蛋白7抗体
别名：dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; Gm430; KIAA1771 ; MGC189434; mKIAA1771; RP23 329P19.2; ZIR2; DOCK7_HUMAN.
浓度：1mg/1ml
规格：0.2ml/200μg          
抗体来源：Rabbit  
克隆类型：polyclonal
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep   
产品类型：胞质分裂专一蛋白7抗体一抗    
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号  
蛋白分子量：predicted molecular weight: 242kDa
性状：Lyophilized or Liquid
免疫原：KLH conjugated synthetic peptide derived from human DOCK7
亚型：IgG
纯化方法：affinity purified by Protein A
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用：ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  

保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍：DOCK 7 is a 2,140 amino acid protein that localizes to developing axons and contains one DHR-1 domain and one DHR-2 domain. Expressed in a variety of tissues, DOCK 7 functions as a guanine nucleotide exchange factor (GEF) that specifically activates Rac 1 and Rac 3 by catalyzing the exchange of bound GDP for free GTP. Multiple isoforms of DOCK 7 exist due to alternative splicing events.

Function : DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.

Subunit : Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.

Subcellular Location : Cell projection,

Tissue Specificity : Widely expressed.

Similarity : Belongs to the DOCK family.

Contains 1 DHR-1 domain.

Contains 1 DHR-2 domain.

Database links : UniProtKB/Swiss-Prot: Q96N67.4胞质分裂专一蛋白7抗体