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价格：电议
所在地：福建 厦门市
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更新时间：2018-08-27
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公司地址：厦门市湖里区长浩一里59#702
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关于慧嘉
厦门慧嘉生物科技有限公司，是一家专业代理国内外知名品牌生命科学试剂产品，产品范围涉及细胞生物学，分子生物学，免疫学及生物化学等实验室科学研究试剂，包括细胞系，细胞培养，ELISA和免疫组化抗体，一抗，二抗，单克隆和多克隆抗体，PCR及放免试剂盒，生化试剂以及各类实验仪器。
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| Catalogue Number | CYT-107 |
| Synonyms | SYM1, SYNS1, NOG. |
| Introduction | The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as NOG. All NOG mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of human noggin is highly homologous to that of Xenopus, rat and mouse. |
| Description | Noggin Human Recombinant produced in HEK cells is a glycosylated homodimer, having a total molecular weight of 65kDa. The Noggin is purified by proprietary chromatographic techniques. |
| Source | HEK. |
| Physical Appearence | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The Noggin was lyophilized from 1mg/ml in 1xPBS. |
| Solubility | It is recommended to reconstitute the lyophilized Noggin in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized Noggin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Noggin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 95% as obsereved by SDS-PAGE. |
| Biological Activity | The specific activity was determined by the dose dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells and is typically 20-100ng/ml. |
| Usage | ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
免责声明：以上所展示的[ 重组人头蛋白, HEK来源/Noggin Human, HEK]信息由会员[厦门慧嘉生物科技有限公司]自行提供，内容的真实性、准确性和合法性由发布会员负责。网站首页 | 最新产品 | 关于我们 | 联系方式 | 网站地图 | 网站留言 | 广告服务 | 浙ICP备10048950号-1
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